메뉴 바로가기
주메뉴 바로가기
컨텐츠 바로가기

R&D

논문

Gene-environment interaction explains a part of missing heritability in human body mass index

작성자 : 멘델
작성일 : 2023-03-28 10:40:03
조회수 : 39

Title : Gene-environment interaction explains a part of missing heritability in human body mass index

 

Abstract : Gene-environment (G×E) interaction could partially explain missing heritability in traits; however, the magnitudes of G×E interaction effects remain unclear. Here, we estimate 

the heritability of G×E interaction for body mass index (BMI) by subjecting genome-wide interaction study data of 331,282 participants in the UK Biobank to linkage disequilibrium score regression (LDSC) and linkage disequilibrium adjusted kinships–software for estimating SNP heritability

from summary statistics (LDAK-SumHer) analyses. Among 14 obesityrelated lifestyle factors, MET score, pack years of smoking, and alcohol intake frequency significantly interact with genetic factors in both analyses, accounting for the partial variance of BMI. The G×E interaction heritability (%) 

and standard error of these factors by LDSC and LDAK-SumHer are as follows: MET score, 0.45% (0.12) and 0.65% (0.24); pack years of smoking, 0.52% (0.13) and 0.93% (0.26); and alcohol intake frequency, 0.32% (0.10) and 0.80% (0.17), respectively. 

Moreover, these three factors are partially validated for their interactions with genetic factors in other obesity-related traits, including waist circumference, hip circumference, waist-to-hip ratio adjusted with BMI, and body fat percentage. 

Our results suggest that G×E interaction may partly explain the missing heritability in BMI, and two G×E interaction loci identified could help in understanding the genetic architecture of obesity.





번호 제목 작성자 작성일
21 Identifcation of asthma-related genes using asthmatic blood eQTLs of Korean patients 멘델 2023-10-31
20 Genetic differences according to onset age and lung function in asthma: A cluster analysis 멘델 2023-08-01
19 나의 유전정보를 이용하면 심장병에 걸릴 가능성이 높은지를 알 수 있는가? 멘델 2023-07-26
18 Investigation of heteroscedasticity in polygenic risk scores across 15 quantitative traits 멘델 2023-05-11
17 Gene-environment interaction explains a part of missing heritability in human body mass index 멘델 2023-03-28
16 The effect of heteroscedasticity on the prediction efficiency of genome-wide polygenic score for body mass index 멘델 2023-02-13
15 Smoking-Interaction Loci Affect Obesity Traits: A Gene-Smoking Stratified Meta-Analysis of 545,131 Europeans 멘델 2023-02-13
14 Gene-environment interaction in type 2 diabetes in Korean cohorts: Interaction of a type 2 diabetes polygenic risk score with triglyceride and cholesterol on fasting glucose levels 멘델 2022-07-19
13 Genome-Wide Interaction Study of Late-Onset Asthma With Seven Environmental Factors Using a Structured Linear Mixed Model in Europeans 멘델 2022-07-19
12 Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction 멘델 2022-07-19
1 2 3
상단 이동